Feasibility study of an Integrated Program for Aerospace-vehicle Design (IPAD) system. Volume 1: Summary

An overview is provided of the Ipad System, including its goals and objectives, organization, capabilities and future usefulness. The systems implementation is also presented with operational cost summaries

Feasibility study of an Integrated Program for Aerospace-vehicle Design (IPAD) system. Volume 6: Implementation schedule, development costs, operational costs, benefit assessment, impact on company organization, spin-off assessment, phase 1, tasks 3 to 8

A baseline implementation plan, including alternative implementation approaches for critical software elements and variants to the plan, was developed. The basic philosophy was aimed at: (1) a progressive release of capability for three major computing systems, (2) an end product that was a working tool, (3) giving participation to industry, government agencies, and universities, and (4) emphasizing the development of critical elements of the IPAD framework software. The results of these tasks indicate an IPAD first release capability 45 months after go-ahead, a five year total implementation schedule, and a total developmental cost of 2027 man-months and 1074 computer hours. Several areas of operational cost increases were identified mainly due to the impact of additional equipment needed and additional computer overhead. The benefits of an IPAD system were related mainly to potential savings in engineering man-hours, reduction of design-cycle calendar time, and indirect upgrading of product quality and performance

The Interplanetary Network Supplement to the BeppoSAX Gamma-Ray Burst Catalogs

Between 1996 July and 2002 April, one or more spacecraft of the interplanetary network detected 787 cosmic gamma-ray bursts that were also detected by the Gamma-Ray Burst Monitor and/or Wide-Field X-Ray Camera experiments aboard the BeppoSAX spacecraft. During this period, the network consisted of up to six spacecraft, and using triangulation, the localizations of 475 bursts were obtained. We present the localization data for these events.Comment: 89 pages, 3 figures. Submitted to the Astrophysical Journal Supplement Serie

The mass of the black hole in GRS 1915+105: new constraints from IR spectroscopy

GRS 1915+105 has the largest mass function of any Galactic black hole system, although the error is relatively large. Here we present spectroscopic analysis of medium-resolution IR VLT archival data of GRS 1915+105 in the K-band. We find an updated ephemeris, and report on attempts to improve the mass function by a refinement of the radial velocity estimate. We show that the spectra are significantly affected by the presence of phase-dependent CO bandhead emission, possibly originating from the accretion disc: we discuss the impact this has on efforts to better constrain the black hole mass. We report on a possible way to measure the radial velocity utilising apparent H-band atomic absorption features and also discuss the general uncertainty of the system parameters of this well-studied objectComment: 7 pages, 7 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journa

TREEOME: A framework for epigenetic and transcriptomic data integration to explore regulatory interactions controlling transcription

Motivation: Predictive modelling of gene expression is a powerful framework for the in silico exploration of transcriptional regulatory interactions through the integration of high-throughput -omics data. A major limitation of previous approaches is their inability to handle conditional and synergistic interactions that emerge when collectively analysing genes subject to different regulatory mechanisms. This limitation reduces overall predictive power and thus the reliability of downstream biological inference. Results: We introduce an analytical modelling framework (TREEOME: tree of models of expression) that integrates epigenetic and transcriptomic data by separating genes into putative regulatory classes. Current predictive modelling approaches have found both DNA methylation and histone modification epigenetic data to provide little or no improvement in accuracy of prediction of transcript abundance despite, for example, distinct anti-correlation between mRNA levels and promoter-localised DNA methylation. To improve on this, in TREEOME we evaluate four possible methods of formulating gene-level DNA methylation metrics, which provide a foundation for identifying gene-level methylation events and subsequent differential analysis, whereas most previous techniques operate at the level of individual CpG dinucleotides. We demonstrate TREEOME by integrating gene-level DNA methylation (bisulfite-seq) and histone modification (ChIP-seq) data to accurately predict genome-wide mRNA transcript abundance (RNA-seq) for H1-hESC and GM12878 cell lines. Availability: TREEOME is implemented using open-source software and made available as a pre-configured bootable reference environment. All scripts and data presented in this study are available online at http://sourceforge.net/projects/budden2015treeome/.Comment: 14 pages, 6 figure

No Evidence for Gamma-Ray Burst/Abell Cluster or Gamma- Ray Burst/Radio-Quiet Quasar Correlations

We examine the recent claims that cosmic gamma-ray bursts are associated with either radio-quiet quasars or Abell clusters. These associations were based on positional coincidences between cataloged quasars or Abell clusters, and selected events from the BATSE 3B catalog of gamma-ray bursts. We use a larger sample of gamma-ray bursts with more accurate positions, obtained by the 3rd Interplanetary Network, to re-evaluate these possible associations. We find no evidence for either.Comment: Accepted for publication in the Astrophysical Journa

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice

Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the amygdaloid complex and other brain regions where monoamines are key regulators of emotional behaviors affected by stress. However, assessing the contribution of OCT3 to the regulation of monoaminergic neurotransmission and monoamine-dependent regulation of behavior requires fundamental information about the subcellular distribution of OCT3 expression. We used immunofluorescence and immuno-electron microscopy to examine the cellular and subcellular distribution of the transporter in the basolateral amygdaloid complex of the rat and mouse brain. OCT3-immunoreactivity was observed in both glial and neuronal perikarya in both rat and mouse amygdala. Electron microscopic immunolabeling revealed plasma membrane-associated OCT3 immunoreactivity on axonal, dendritic, and astrocytic processes adjacent to a variety of synapses, as well as on neuronal somata. In addition to plasma membrane sites, OCT3 immunolabeling was also observed associated with neuronal and glial endomembranes, including Golgi, mitochondrial and nuclear membranes. Particularly prominent labeling of the outer nuclear membrane was observed in neuronal, astrocytic, microglial and endothelial perikarya. The localization of OCT3 to neuronal and glial plasma membranes adjacent to synaptic sites is consistent with an important role for this transporter in regulating the amplitude, duration, and physical spread of released monoamines, while its localization to mitochondrial and outer nuclear membranes suggests previously undescribed roles for the transporter in the intracellular disposition of monoamines

SGR 1806-20 Is a Set of Independent Relaxation Systems

The Soft Gamma Repeater 1806-20 produced patterns of bursts during its 1983 outburst that indicate multiple independent energy accumulation sites, each driven by a continuous power source, with sudden, incomplete releases of the accumulated energy. The strengths of the power sources and their durations of activity vary over several orders of magnitude.Comment: Accepted ApJLett, 15 pages, 3 figure

Stereoscopic observations of hard x ray sources in solar flares made with GRO and other spacecraft

Since the launch of the Gamma Ray Observatory (GRO) in Apr. 1991, the Burst and Transient Source Experiment (BATSE) instrument on GRO has recorded a large number of solar flares. Some of these flares have also been observed by the Gamma-Ray Burst Detector on the Pioneer Venus Orbiter (PVO) and/or by the Solar X-Ray/Cosmic Gamma-Ray Burst Experiment on the Ulysses spacecraft. A preliminary list of common flares observed during the period May-Jun. 1991 is presented and the possible joint studies are indicated